Usual range: 2-20 mcg/kg/min
0 mL/hr
Predominantly α1 agonist, some β1 activity
Pure α1 agonist
| Agent | Mechanism | Indications | Key Considerations |
|---|---|---|---|
| Dobutamine | β1 agonist | Low CO, high SVR, cardiogenic shock (BP > 90) | Tachycardia, arrhythmias |
| Dopamine | Dose-dependent | Limited role; avoid if possible | Nausea/vomiting, tissue necrosis with extravasation |
| Noradrenaline | α1, β1 agonist | Hypotension, septic shock, cardiogenic shock | Peripheral necrosis, rebound hypotension |
| Adrenaline | α, β agonist | Cardiac arrest, peri-arrest, anaphylaxis | Arrhythmias, hyperglycemia, renal impairment |
| Milrinone | PDE3 inhibitor | Acute decompensated HF, RV failure | Hypotension with loading dose, thrombocytopenia |
| Levosimendan | Ca sensitizer, PDE3 inhibitor | Acute decompensated HF | Expensive, headache, AF risk |
| Digoxin | Na/K ATPase inhibitor | Chronic HF, AF with rapid VR | Narrow therapeutic window, drug interactions |
Advanced Inotrope & Vasopressor Engine
The Advanced Inotrope & Vasopressor Engine is an advanced clinical decision-support tool designed to assist healthcare professionals in accurately calculating, titrating, and optimizing vasoactive medications in critically ill patients. Built for rapid bedside use, it integrates weight-based dosing, infusion preparation, and hemodynamic goals to support safe and effective cardiovascular support.
This tool simplifies the complex management of inotropes and vasopressors by providing precise dose calculations and titration guidance. It helps clinicians maintain hemodynamic stability while minimizing medication errors in high-acuity settings such as the ICU and emergency department.
Users input key patient and drug parameters such as:
Patient weight
Selected vasoactive agent
Desired dose (mcg/kg/min or units/min)
Infusate concentration
Target mean arterial pressure (MAP) or perfusion goal
The calculator instantly generates infusion rates, preparation instructions, and titration guidance aligned with critical care practices.
Weight-based dose calculator
Multi-agent support (e.g., norepinephrine, dopamine, dobutamine, epinephrine)
Infusion rate auto-calculation (mL/hr)
Standard dilution guidance
Titration and escalation support
Hemodynamic goal targeting
Safety checks to reduce dosing errors
ICU-friendly rapid interface
Mobile and bedside optimized
Intensivists
Emergency physicians
Anesthesiologists
Critical care nurses
Residents and fellows
Transport and code teams
Improves dosing accuracy in high-risk medications
Reduces bedside calculation time
Enhances patient safety
Standardizes vasoactive therapy
Supports rapid decision-making in shock states
Minimizes infusion preparation errors
This calculator is intended for educational and clinical decision-support purposes only. Final dosing and titration should always follow institutional protocols and clinician judgment.